Integrated systems for high-fidelity sensing and manipulation of brain neurochemistry

This paper presents an overview of two state-of-the-art integrated systems fabricated in 0.35μm 2P/4M CMOS for high-fidelity sensing and manipulation of brain neurochemistry. The first system has been developed for neurochemical pattern generation, combining electrical stimulation for generation of user-defined dopamine temporal patterns with neurochemical sensing for subsequent assessment of fidelity in the generated profiles. T he second system has been developed for closed-loop regulation of brain neurochemistry and uniquely integrates neurochemical sensing, real-time chemometrics, and feedback-controlled electrical stimulation to mimic a neurochemostat by maintaining the brain levels of electrically evoked dopamine between two user-defined thresholds. Measured results from biological experiments with anesthetized rats are also presented.