Laboratory Diagnosis of Antiphospholipid Syndrome

The diagnosis of antiphospholipid syndrome (APS) is essentially based on the detection of circulating antiphospholipid antibodies (aPL).Reading and interpretation of aPL profiles may be challenging and results of aPL should be interpreted in view of clinical context.The international diagnostic criteria of APS were developed and revised by international experts and societies, publishing international consensus guidelines on the recommended best practices for technical and performance requirements.Despite these attempts to produce consensus guidelines, some issues related to laboratory testing still remain unresolved.In this review, we want to give an overview of laboratory testing for APS with summary of recent international consensus guidelines for the detection of aPL.Also a brief review of prognostic significance of aPL profile and potential future diagnostic assay is presented.