Experimental investigation was conducted to explore the heat-transport capability of pulsating heat pipe(PHP) working with different working fluids.The heat transfer characteristics of PHP with water as working fluid were studied under different liquid filling rates,different heat loads and different inclination angles(0°and 90°).The heat-transport capabilities of pulsating heat pipes with different working fluids(FS-39E microcapsule fluid,water,Al2O3 nano-fluid) were compared.The results showed that the heat-transport capability of PHP could be enhanced by using functional thermal fluids(FS-39E microcapsule fluid and Al2O3 nano-fluid) as working fluid under specific condition.When using vertical bottom heating mode(inclination angle=90°),1% FS-39E microcapsule fluid was the better working fluid.When using horizontal heating mode(inclination angle=0°),0.1% Al2O3 nano-fluid was the better working fluid.But the stability of microcapsule fluid was much better than Al2O3 nano-fluid.