Analysis of serum concentration of aminophylline for treating asthma in pediatrics

Objective: To observe the correlation between the serum concentration of aminophylline and the clinical effect on pediatric patients with asthma, and to study the factors that affect the serum concentration of aminophylline. Meth ods: The data of 43 pediatric patients with asthma whose serum concentration of aminophylline were determined were assessed retrospectively. Results: The averag e serum concentration of aminophylline was 12.89±5.19 mg/L. 86.0% of the cases had the effective serum concentration of aminophylline (5~20 mg/L). None exceede d 20 mg/L. Combined-usage of drugs always effect the serum concentration of amin ophylline. Conclusions: There is great individual difference in the serum concen tration of aminophylline. It is important to monitor the serum concentration of aminophylline in order to assure the clinical effect.