Assessing propofol induction of anesthsia dose and effect on hemodynamic using bispectral index analysis

Objecive In this study we sought to determine the propofol requirement and hemodynamic effects as guided by bispectral index(BIS) analysis during induction of anesthesia.Methods Ninety patients were enrolled in this study.Propofol,20mg/(kg·h),was given to Group Ⅰ,Group Ⅱ,Group Ⅲ for induction.Propofol was administered for induction until loss of response to verbal commands and until BIS values were around 50 to Groups Ⅱ and Ⅲ.Results The smallest BIS value was significantly different in Group Ⅰ.SBP was lower in Group Ⅰ than the other groups after anesthesia induction.The total propofol doses were(149.7±10.8)mg,(112.8±10.2)mg,and(91.3±11.4)mg in Groups Ⅰ,Ⅱ,and Ⅲ,respectively.Decreases in total propofol dose were 33%and 47%in Groups Ⅱ and Ⅲ respectively as compared with Group Ⅰ.Conclusion The induction dose of propofol assessed by BIS analysis results in an important dose reduction without sied effects.