A method of water injection profile control is combined with water shut off in prooduction well for the oilfield in high water cut period. The comprehensive method was applied in 5 6 unit of Gudong region. The wells for profile control and water shut off are selected based on the fuzzy theory. The process parameters are designed based on the corresponding expert system. Based on the producing and injection behaviors, the technology of agent combination is adapted to the formation condition. After the project is carried out, the apparent injectivity indices of the treated injection well are reduced. The injection profile is improved. The water cut of corresponding production well decreases, and the oil production rate increases. It is indicated that this set of technology is effective for improving water flooding effect of oilfield in high water cut period.