Hypoxic Preconditioning Increases Expression of VEGF in the Hippocampus of Mice

Objective:To detect the effect of hypoxia preconditioning on vascular endothelial growth factor(VEGF) expression in acute repeated hypoxic mice hippocampus.Methods:Mice were divided into 3 groups randomly and were exposed to hypoxia for 4 runs(H4 group),1 run(H1 group) and 0 run(control group).Western Blot was used to examine the VEGF level in mice hippocampus following exposure to hypoxia.total protein was extracted from mice hippocampus for Western blot.Results:VEFG were found in H0,H1 and H4 group.VEGF protein levels were found to be increased markedly in H4(P0.05,vs.H1 and H0).There is no difference between H1 and H0.Conclusion: The change of VEGF protein level is closely related to protection of the brain and the formation of preconditioning in hypoxic preconditioned mice.