Clinical observation of effect of donepezil in treating Alzhemer's disease

Objective To investigate the effect of donepezil in treating patients with Alzheimer's disease on cognitive disfunction and lacking of capablity of daily living.Methods140 patient's with Alzheimer's disease were randomly divided into treatment group(treated with donepezil)and control group(treated without donepezil).MMSE Scale and ADL Scale of the two groups were assessed before treatment and 1 months、3 months and 6 months af ter treatment.ResultsThe MMSE Scale and ADL Scale of the treatment group were improved more greatly than the control group(P0.05),and the therapeutical effect enhanced as the time of therapy expanded.After treated with donepezil for 1 month、2 months、6 months,the effective percentage of donepezil in treating AD patients with congnitive disfunction are respectively13%、32%、43%hgher than without donepezil,and in treating AD patients lacking of capablity of daily living are respectively 8%、13%、23%hgher than without donepezil.ConclusionDonepezil effectively improves cognition and preserves function in individuals with Alzheimer's disease.