The effect observation of preoperative instillation of pirarubicin in the second transurethral resection of bladder tumor

Objective To investigate the effect of pirarubicin in the second transurethral resection of bladder tumor.Methods Fifty patients with urothelial carcinoma were divided into two groups: one was the second transurethral resection group(TURB-t group) and another was TURB-t plus pirarubicin instillation group(TURB-t+THP group).In the TURB-t group routine TURB-t was applied while in the TURB-t+THP group,40 mg of pirarubicin was instilled into bladder before operation.Results All patients were followedup for 24 months after operation.In the TURB-t group,6 patients progressed and 16 patients suffered from recurrence while in the TURB-t+THP group 3 patients progressed and 11 patients suffered from recurrence.The differences were statistically significant.Conclusion The preoperational instillation of pirarubicin could improve the patients' prognosis with bladder-urothelial carcinoma.