Objective: To evaluate the value of treadmill exercise testing (TET) for diagnosis of coronary artery disease (CAD). Methods: Coronary angiography (CAG) and TET were done for 262 patients. The interval between these two procedures is less than one month. CAG data were compared with that of TET. Results: The sensitivity, specificity and accuracy rate of TET for diagnosis of CAD was 60.42% (58/96), 69.88% (116/166), 66.41% (174/ 262), respectively. There was a significant difference between the CAG positive group and CAG negative group in the exercise time, maximum METs and blood pressure at exercise peak (P0. 05). There was also a significant difference between the multiple vessel disease group and the single vessel disease group (P0. 05) . The patients with multiple vessel disease had a higher positive rate of TET as compared with that of single vessel disease (P0. 05). Conclusion : TET is an effective non-invasive method in the diagnosis of CAD. Some parameters in TET are helpful to predict the severity of CAD.