Objective: To compare the clinical effect of zudan and metoclopramide on controling vomiting caused by cisplatin. Methods: 20 patients were randornly divided into two groups: group BA (n=10) and group AB (n=10).Zudan and metoclopramide were respectively given to them in different phases. The curative effect and side effect were observed. Results: The effective rate was 70% for zudan,30% for metoclopramide,and the side effect of zudan hadn't been observed. Conclusion: These results suggest that zudan may be more effective and safer than metoclopramide.