Back to pluripotency: fully chemically induced reboot of human somatic cells

Guan, J. et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605 , 325–331 (2022). Article CAS Google Scholar Kim, J. Y., Nam, Y., Rim, Y. A. & Ju, J. H. Review of the Current Trends in Clinical Trials Involving Induced Pluripotent Stem Cells. Stem Cell Rev. Rep. 18 , 142–154 (2022). Article Google Scholar Hou, P. et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341 , 651–654 (2013). Article CAS Google Scholar Liu, J. et al. The oncogene c-Jun impedes somatic cell reprogramming. Nat. Cell Biol. 17 , 856–867 (2015). Article CAS Google Scholar Murugan, N. J. et al. Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis. Sci. Adv. 8 , eabj2164 (2022). Article CAS Google Scholar Download references