血管生成
基因亚型
选择性拼接
血管内皮生长因子
癌症研究
血管内皮生长因子受体
微血管
生物
细胞生物学
生长因子
RNA剪接
生物化学
基因
受体
核糖核酸
作者
Steven J. Harper,David O. Bates
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2008-10-16
卷期号:8 (11): 880-887
被引量:439
摘要
The physiology of microvessels limits the growth and development of tumours. Tumours gain nutrients and excrete waste through growth-associated microvessels. New anticancer therapies target this microvasculature by inhibiting vascular endothelial growth factor A (VEGF-A) splice isoforms that promote microvessel growth. However, certain VEGF-A splice isoforms in normal tissues inhibit growth of microvessels. Thus, it is the VEGF-A isoform balance, which is controlled by mRNA splicing, that orchestrates angiogenesis. Here, we highlight the functional differences between the pro-angiogenic and the anti-angiogenic VEGF-A isoform families and the potential to harness the synthetic capacity of cancer cells to produce factors that inhibit, rather than aid, cancer growth.
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