Late Blight of potato ( Phytophthora infestans ) remains the major disease throughout the world. To check the resistance/ susceptibility, thirty potato genotypes were planted for screening against late blight disease at Potato Research Institute, Sahiwal during the year 2010-11. Outbreak of late blight of potato caused by Phytophthora infestans have induced significant yield losses in the past and still a major threat to potato production in Pakistan. Potato genotypes were evaluated for their tolerance to late blight disease. Results revealed that eighteen genotypes expressed resistant response towards disease whereas two genotypes i.e. FD 8-1, and FD 52-2 showed moderately resistant. Similarly the genotype SH-70 exhibited moderately susceptible and four genotypes i.e. FD 49-62, FD 19-2, SH-473 and Hermes showed susceptible response towards disease. Hence it is concluded that the resistant genotypes could be used as a source in future potato breeding projects against phytophthora infestans..