THE DISADVANTAGES OF SULFONAMIDE COMBINATIONS

Case Reports1 September 1948THE DISADVANTAGES OF SULFONAMIDE COMBINATIONSWILFRED CARROL, M.D.WILFRED CARROL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-3-533 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently there have appeared reports in the literature advocating the use of "sulfonamide combinations."1, 2The purpose in giving combinations of these similarly acting drugs has been to reduce the danger of "intrarenal drug precipitation" and "concrement formation." While giving comparatively small doses of each component of a mixture of sulfonamides, the danger of intrarenal drug precipitation should be only as great as if each compound had been administered alone. Yet the sum of the components could be completely effective in eradication of a given infection. This method of sulfonamide therapy at first sight appears very desirable but a case...Bibliography1. LEHR D: Inhibition of drug precipitation in the urinary tract by the use of sulfonamide mixtures. I. Sulfathiazole-sulfadiazine mixture, Proc. Soc. Exper. Biol. and Med., 1945, lviii, 11. CrossrefGoogle Scholar2. FRISKHAGENMANHELANDERSJÖGREN ARGSB: "Sulfa-Combination," New chemotherapeutic principle, British Med. Jr., 1947, l, 7. CrossrefGoogle Scholar3. BLANKENHORNVILTER MACF: Toxic reactions of the newer sulfonamides, Jr. Am. Med. Assoc., 1944, cxxvi, 691. Google Scholar4. FINLANDPETERSONGOODWIN MOLRA: Sulfadiazine, further clinical studies of its efficacy and toxic effects, Ann. Int. Med., 1942, xvii, 920. Google Scholar5. DOWLINGLEPPER HFMH: Toxic reactions following therapy with sulfapyridine, sulfathiazole and sulfadiazine, Jr. Am. Med. Assoc., 1943, cxxi, 1190. CrossrefGoogle Scholar6. DOWLING HF: Relative toxicity of sulfamerazine and sulfadiazine, Jr. Am. Med. Assoc., 1944, cxxv, 103. CrossrefGoogle Scholar7. SCHWARTZFLIPPINREINHOLDDOMM LHFJGAH: The effects of alkali on crystalluria from sulfathiazole and sulfadiazine, Jr. Am. Med. Assoc., 1941, cxvii, 514. CrossrefGoogle Scholar8. GILLIGANGARBPLUMMER DRSN: Prevention of crystalluria during sulfadiazine therapy, Proc. Soc. Exper. Biol. and Med., 1943, lii, 248. CrossrefGoogle Scholar9. GILLIGANGARBWHEELERPLUMMER DRSCN: Adjuvant alkali therapy in prevention of renal complications from sulfadiazine, Jr. Am. Med. Assoc., 1943, cxxii, 1160. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Newark, N. J.*Received for publication July 31, 1947. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntibacterial Chemotherapy with Sulfonamides 1 September 1948Volume 29, Issue 3Page: 533-536KeywordsDrugsSulfonamide ePublished: 1 December 2008 Issue Published: 1 September 1948 PDF downloadLoading ...