DNA甲基化
生物
RNA导向的DNA甲基化
体育锻炼的表观遗传学
DNMT1型
表观遗传学
脱甲基酶
甲基化
甲基转移酶
DNA甲基转移酶
甲基化DNA免疫沉淀
癌症表观遗传学
DNA复制
DNA
表观遗传学
遗传学
分子生物学
基因
基因表达
作者
Moshe Szyf,Nancy Detich
出处
期刊:Progress in Nucleic Acid Research and Molecular Biology
日期:2001-01-01
卷期号:: 47-79
被引量:49
标识
DOI:10.1016/s0079-6603(01)69044-5
摘要
Deoxyribonucleic acid (DNA) methylation, a covalent modification of the genome, is emerging as an important player in the regulation of gene expression. This chapter discusses the different components of the DNA methylation machinery responsible for replicating the DNA methylation pattern. A number of DNA methyltransferases (DNMT) have been identified and a demethylase has recently been reported. Because the DNA methylation pattern is critical for gene expression programs, the cell possesses a number of mechanisms to coordinate DNA replication and methylation. DNMT levels are regulated, with the cell cycle, and are induced upon the entry into the S-phase of the cell cycle. Overexpression of DNMT1 is probably not responsible for the aberrant methylation of tumor suppressor genes. Unraveling how the different components of the DNA methylation machinery interact to replicate the DNA methylation pattern and how they are disrupted in cancer, it is critical to understand the molecular mechanisms of cancer.
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