戊型肝炎病毒
医学
怀孕
戊型肝炎
入射(几何)
丙氨酸转氨酶
抗体
病毒学
免疫学
内科学
基因型
生物
基因
遗传学
物理
光学
生物化学
作者
Manyu Li,Qiuning Bu,Weibin Gong,Haomin Li,Lin Wang,Shuangshuang Li,Siddharth Sridhar,Patrick C. Y. Woo,Ling Wang
标识
DOI:10.1080/14767058.2019.1582630
摘要
Background and aims: The aim of this study was to investigate the positive rate of hepatitis E virus (HEV) infection and the possible adverse outcomes in pregnant women of Qinhuangdao, China.Methods: Serum samples of 946 pregnant women were collected from July 2017 to October 2017 in Qinhuangdao First Hospital. All samples were tested for anti-HEV IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). HEV RNA was tested by reverse transcription-nested polymerase chain reaction (RT-nPCR) and the PCR products were sequenced.Results: Of the 946 samples, the positive rate of anti-HEV IgM (15/365, 4.11%), anti-HEV IgG (74/365, 20.27%) and both anti-HEV IgM and IgG (12/365, 3.29%) were significantly higher (p < .05) in third trimester pregnant women than in the first (3/288, 1.04%; 36/288, 12.5%; 4/288, 1.39%), and second trimesters (6/293, 2.05%; 29/293, 9.90%; 2/293, 0.68%). The average alanine transaminase (ALT) level (34.49 ± 10.15) and the incidence of adverse pregnancy outcomes (13/18, 72.22%) in the both anti-HEV IgM and IgG positive group were significantly higher than other groups (p < .05). HEV RNA was detected in 1/181 (0.55%) of pregnant women with a history of HEV infection and the detected HEV strain belonged to subgenotype 4a.Conclusions: This study showed that pregnant women who have HEV infection can possibly lead to adverse pregnancy outcomes.
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