材料科学
介孔材料
脚手架
生物活性玻璃
聚合物
表面改性
分子
化学工程
药物输送
氢键
纳米技术
有机化学
化学
复合材料
生物医学工程
催化作用
工程类
医学
作者
Yuchun Xu,Yongbin Hu,Pei Feng,Wenjin Yang,Cijun Shuai
标识
DOI:10.1016/j.ceramint.2019.06.019
摘要
Mesoporous materials have attracted widespread attention in the field of drug delivery. Nevertheless, the weak interfacial interaction between them and drug molecules affects drug loading capacity and release kinetics. In this work, mesoporous bioactive glass (MBG) was functionalized via polydopamine to enhance the interfacial interaction with dexamethasone (DEX). Concretely, on the one hand, the amine groups of polydopamine could form hydrogen bonds with the hydroxyl groups of MBG. On the other hand, the catechol groups could form π-π bonds with the benzene rings of DEX molecules. Subsequently, DEX-loaded polydopamine-functionalized MBG ([email protected]) was incorporated into polyglycolic acid/poly-1-lactic acid (PGPL) to construct a scaffold (PGPL/[email protected]) via laser additive manufacturing process. The results indicated that the loadage of DEX increased by about 40% after polydopamine functionalization, from 1.28 to 1.75 μg/mg. More importantly, the burst effect was avoided. The enhanced intermolecular interaction between pMBG and DEX may be primarily responsible for this phenomenon, as it acts as a driving force to drug loading and a restraining force to drug release. PGPL/[email protected] scaffold also exhibited significantly enhanced cell differentiation, mechanical properties and biomineralization activity.
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