京尼平
槲皮素
化学
Zeta电位
儿茶素
阿布茨
DPPH
壳聚糖
纳米颗粒
抗氧化剂
枯草芽孢杆菌
抗菌活性
核化学
有机化学
多酚
纳米技术
材料科学
细菌
生物
遗传学
作者
Feng Li,Huimiao Jin,Jie Xiao,Xusheng Yin,Xinying Liu,Qingrong Huang
标识
DOI:10.1016/j.foodres.2018.05.038
摘要
A novel chitosan-based nanoparticle (G-C-Q NPs), which simultaneously loaded catechin and quercetin, was synthesized through ionic gelation reaction between chitosan and sodium tripolyphosphate and subsequent modification by genipin. Chemical structure, size distribution, morphology, entrapment efficiency, in vitro release behavior, antioxidant and antibacterial effects of G-C-Q NPs were investigated. Results showed that G-C-Q NPs were dispersed as an ellipsoidal shape with an average diameter of 180.4 nm and a zeta potential of 31.79 ± 1.28 mV. Entrapment efficiency of catechin and quercetin reached 76.35 ± 1.37% and 52.23 ± 2.45%, respectively. In vitro release study showed that both catechin and quercetin had a sustainable release from the G-C-Q NPs. G-C-Q NPs had higher or comparable potency in scavenging DPPH, ABTS+, OH and O2- radicals and in suppressing growing of Escherichia coli, Bacillus subtilis Staphylococcus aureus as compared to native drugs (single or combination). These results contribute some basis to the design and fabrication of polymeric nanoparticle delivery systems for multiple bioactive compounds with beneficial properties.
科研通智能强力驱动
Strongly Powered by AbleSci AI