Association Between Hospital-Level Volume of Extracorporeal Membrane Oxygenation and Complications: A Clustered, Mixed-Effect Analysis of the Extracorporeal Life Support Organization Registry

Higher annual center-volumes of ECMO were associated with decreased pulmonary complications for VV, decreased hemorrhagic complications for VA and VV cohorts and an increase in mechanical complications for VA cohort but not ECPR alone. These associations were small, with a 0.3% increase or decrease in odds per complication category, but are attributable entirely to the center volume and known at the moment of ECMO cannulation.