化学
卡宾
机械合成
催化作用
反应性(心理学)
组合化学
过渡金属卡宾配合物
有机化学
偶联反应
立体化学
作者
Dmytro Ryzhakov,Audrey Beillard,Franck Le Bideau,Riyadh Ahmed Atto Al-Shuaeeb,Mouad Alami,Xavier Bantreil,Aurore Bonnemoy,Arnaud Gautier,Samir Messaoudi
标识
DOI:10.1002/ejoc.202101499
摘要
A versatile protocol for the synthesis of azolium thioglycosides is reported. This protocol is based on a PdG3-catalyzed Migita cross-coupling between p-di-iodo azoliums and protected or unprotected β-1-thioglucose partners. Moreover, a solvent-free mechanochemistry approach was developed as a unique access to the corresponding Ag(I)-N-heterocyclic carbene thioglycosides. Finally, chemical reactivity and antiproliferative bioactivity were examined with azoliums and Ag(I)-NHC thioglycosides. This study demonstrates a promising potential of these newly synthesized carbohydrate-based N-heterocyclic derivatives.
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