磺酰
光催化
磺胺
表面改性
光催化
烯烃
催化作用
化学
光化学
功能群
分子
组合化学
有机化学
物理化学
聚合物
烷基
作者
Michael J. Tilby,Damien F. Dewez,Loïc Pantaine,Adrian Hall,Carolina Martínez-Lamenca,Michael C. Willis
标识
DOI:10.1021/acscatal.2c01442
摘要
A plethora of drug molecules and agrochemicals contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy is described, which allows sulfonamides to be converted to pivotal sulfonyl radical intermediates. This methodology exploits a metal-free photocatalytic approach to access radical chemistry, which is harnessed by combining pharmaceutically relevant sulfonamides with an assortment of alkene fragments. Additionally, the sulfinate anion can be readily obtained, further broadening the options for sulfonamide functionalization. Mechanistic studies suggest that energy-transfer catalysis (EnT) is in operation.
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