化学
芳基
催化作用
铱
卤化物
镍
组合化学
盐(化学)
光催化
催化循环
表面改性
有机化学
烷基
物理化学
作者
Christopher S. Gravatt,Jeffrey W. Johannes,Eric R. King,Avipsa Ghosh
标识
DOI:10.1021/acs.joc.2c00631
摘要
While trifluoromethylthiolation of aryl halides has been extensively explored, the current methods require complex and/or air-sensitive catalysts. Reported here is a method employing a bench-stable Ni(II) salt and an iridium photocatalyst that can mediate the trifluoromethylthiolation of a wide range of electronically diverse aryl and heteroaryl iodides, likely via a Ni(I)/Ni(III) catalytic cycle. The reaction has broad functional group tolerance and potential for application in medicinal chemistry, as demonstrated by a late-stage functionalization approach to access (racemic)-Monepantel.
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