代谢途径
生物
可药性
转移
癌细胞
生物能学
谷氨酰胺
癌症
癌症研究
糖酵解
自噬
重编程
代谢网络
谷氨酰胺分解
厌氧糖酵解
生物信息学
新陈代谢
细胞
生物化学
线粒体
氨基酸
遗传学
细胞凋亡
基因
作者
Chiara Raggi,Maria Letizia Taddei,Colin Rae,Chiara Braconi,Fabio Marra
标识
DOI:10.1016/j.jhep.2022.04.038
摘要
Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the increased energy demands required for rapid proliferation, invasion, and metastasis. Indeed, many tumour cells acquire distinctive metabolic and bioenergetic features that enable them to survive in resource-limited conditions, mainly by harnessing alternative nutrients. Several recent studies have explored the metabolic plasticity of cancer cells with the aim of identifying new druggable targets, while therapeutic strategies to limit the access to nutrients have been successfully applied to the treatment of some tumours. Cholangiocarcinoma (CCA), a highly heterogeneous tumour, is the second most common form of primary liver cancer. It is characterised by resistance to chemotherapy and poor prognosis, with 5-year survival rates of below 20%. Deregulation of metabolic pathways have been described during the onset and progression of CCA. Increased aerobic glycolysis and glutamine anaplerosis provide CCA cells with the ability to generate biosynthetic intermediates. Other metabolic alterations involving carbohydrates, amino acids and lipids have been shown to sustain cancer cell growth and dissemination. In this review, we discuss the complex metabolic rewiring that occurs during CCA development and leads to unique nutrient addiction. The possible role of therapeutic interventions based on metabolic changes is also thoroughly discussed.
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