毒力
肺炎克雷伯菌
微生物学
生物
噬菌体
噬菌体疗法
血清型
病毒学
克雷伯菌
多重耐药
细菌
抗生素耐药性
质粒
抗生素
基因
大肠杆菌
遗传学
作者
Peter V. Evseev,M. A. Shneider,YuV Mikhailova,Andrey Shelenkov,YuG Yanushevich,MG Karlova,Andrey Moiseenko,Olga S. Sokolova,Dmitry A. Shagin
出处
期刊:Bulletin of Russian State Medical University
[Pirogov Russian National Research Medical University]
日期:2021-12-01
卷期号: (2021(6))
被引量:1
标识
DOI:10.24075/brsmu.2021.068
摘要
Multidrug-resistant Klebsiella pneumoniae strains are one of the major causes of nosocomial infections caused by the antibiotic-resistant bacteria. There are different options for dealing with this threat, among which is the clinical application of bacteriophages. The study was aimed to isolate and describe a virulent bactriophage, having the potential for therapeutic use. The standard phage biology and bioinformatic methods were used, which included the advanced techniques for protein structure prediction (AlphaFold software), and electron microscopy. The virulent podovirus KPPK108.1, being the member of genus Drulisvirus, which is able to specifically infect the K. pneumoniae strains with the KL108 type capsular polysaccharide, has been isolated from the wastewater. The sequence of the bactriophage genome has been defined, the biological properties have been investigated, and the genetic features have been described.
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