化学
亚胺离子
有机催化
立体中心
对映选择合成
激进的
催化作用
胺气处理
组合化学
戒指(化学)
有机化学
作者
Thomas Hin‐Fung Wong,Daowei Ma,Riccardo Di Sanza,Paolo Melchiorre
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-02-24
卷期号:24 (8): 1695-1699
被引量:13
标识
DOI:10.1021/acs.orglett.2c00326
摘要
We describe an asymmetric organocatalytic method to synthesize 1,7-dicarbonyl compounds containing a β-stereocenter. The chemistry relies on the formation of γ-keto radicals, generated upon oxidative ring opening of cyclobutanols mastered by an organic photoredox catalyst. These nonstabilized primary radicals are stereoselectively intercepted by an iminium ion intermediate, formed upon activation of aliphatic and aromatic enals by a chiral secondary amine catalyst. This organocatalytic photoredox method served to prepare scaffolds found in natural products and drug molecules.
科研通智能强力驱动
Strongly Powered by AbleSci AI