医学
放射外科
放射治疗
磁共振成像
肿瘤科
临床试验
癌症
内科学
放射科
作者
Yoshitaka Narita,Shinya Sato,Takamasa Kayama
出处
期刊:Japanese Journal of Clinical Oncology
[Oxford University Press]
日期:2021-12-02
卷期号:52 (1): 3-7
摘要
Brain metastases (BM) occur in at least 10% of cancer patients, and are one of the main causes of cancer-related deaths and significant deterioration in the quality of life of cancer patients due to the neurological deterioration caused by brain compression and tumor invasion. Whole-brain irradiation has been emphasized as the standard treatment for BM. However, recent clinical trials including the JLGK0901 and JCOG0504 trials conducted in Japan have established therapeutic evidence for the use of stereotactic radiosurgery with regular follow-up with magnetic resonance imaging for BM. In addition to surgery and stereotactic radiotherapy, advances in drug therapy for BM, such as tyrosine kinase inhibitors and immune checkpoint inhibitors, are expected. This review describes the history and the recent evidence of the diagnosis and treatment of BM.
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