纳米载体
耐受性
重症监护医学
医学
背景(考古学)
抗生素
药物输送
临床试验
抗菌剂
抗生素耐药性
药品
抗药性
药理学
纳米技术
生物
微生物学
内科学
不利影响
材料科学
古生物学
作者
María Moreno-Sastre,Marta Pastor,Claudio J. Salomón,Amaia Esquisabel,José Luís Pedraz
摘要
As the WHO stated, lower respiratory infections are the third leading cause of death. In addition, it is remarkable that antimicrobial resistance represents a huge threat. Thus, new therapeutic weapons are required. Among the possible alternatives, antibiotic encapsulation in nanoparticles has gained much attention in terms of improved tolerability, activity and ability to combat the resistance mechanisms of bacteria. In this regard, this review article focuses on the latest nanocarrier approaches for inhalatory therapy of antibiotics. First, the technology related to lung disposition will be reviewed. Then, nanocarrier systems will be introduced and the challenges required to perform adequate pulmonary deposition analysed. In the following part, drug delivery systems (DDSs) on the market or in clinical trials are described and, finally, new approaches of nanoparticles that have reached pre-clinical stage are enumerated. Altogether, this review aims at gathering together the novel nanosystems for anti-infectious therapy, underlining the potential of DDSs to improve and optimize currently available antibiotic therapies in the context of lung infections.
科研通智能强力驱动
Strongly Powered by AbleSci AI