Kinetic Studies on the Palladium(II)‐Catalyzed Oxidative Cross‐Coupling of Thiophenes with Arylboron Compounds and Their Mechanistic Implications

Abstract Reaction orders for the key components in the palladium(II)‐catalyzed oxidative cross‐coupling between phenylboronic acid and ethyl thiophen‐3‐yl acetate were obtained by the method of initial rates. It turned out that the reaction rate not only depended on the concentration of palladium trifluoroacetate (reaction order: 0.97) and phenylboronic acid (reaction order: 1.26), but also on the concentration of the thiophene (reaction order: 0.55) and silver oxide (reaction order: −1.27). NMR spectroscopy titration studies established the existence of 1:1 complexes between the silver salt and both phenylboronic acid and ethyl thiophen‐3‐yl acetate. A low inverse kinetic isotope effect ( k H / k D =0.93) was determined upon employing the 4‐deuterated isotopomer of ethyl thiophen‐3‐yl acetate and monitoring its reaction to the 4‐phenyl‐substituted product. A Hammett analysis performed with para ‐substituted 2‐phenylthiophenes gave a negative ρ value for oxidative cross‐coupling with phenylboronic acid. Based on the kinetic data and additional evidence, a mechanism is suggested that invokes transfer of the phenyl group from phenylboronic acid to a 1:1 complex of palladium trifluoroacetate and thiophene as the rate‐determining step. Proposals for the structure of relevant intermediates are made and discussed.