抄写(语言学)
一般转录因子
DNA损伤
生物
细胞生物学
转录因子
基因
癌变
DNA修复
基因组不稳定性
基因表达
塔夫2
DNA
遗传学
发起人
增强子
哲学
语言学
作者
Dimitrios Papadopoulos,Leonie Uhl,Stefanie Anh Ha,Martin Eilers
标识
DOI:10.1016/j.trecan.2023.06.008
摘要
MYC oncoproteins are key drivers of tumorigenesis. As transcription factors, MYC proteins regulate transcription by all three nuclear polymerases and gene expression. Accumulating evidence shows that MYC proteins are also crucial for enhancing the stress resilience of transcription. MYC proteins relieve torsional stress caused by active transcription, prevent collisions between the transcription and replication machineries, resolve R-loops, and repair DNA damage by participating in a range of protein complexes and forming multimeric structures at sites of genomic instability. We review the key complexes and multimerization properties of MYC proteins that allow them to mitigate transcription-associated DNA damage, and propose that the oncogenic functions of MYC extend beyond the modulation of gene expression.
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