硼酸化
化学
铱
催化作用
光化学
药物化学
有机化学
烷基
芳基
作者
Janis Mikelis Zakis,Antonis M. Messinis,Lutz Ackermann,Tomáš Šmejkal,Joanna Wencel‐Delord
标识
DOI:10.1002/adsc.202301411
摘要
We report a new class of isolable bis‐cyclometallated iridium precatalysts (ImIr) and their use in regioselective ortho‐C–H borylation of aromatic, heteroaromatic, acrylic, and aliphatic systems. The catalysts consist of two imine ligands and an acetate coordinated to an iridium (III) center. The isolable character of ImIr warrants its compatibility with high‐throughput experimentation, a prerequisite for applications in late‐stage functionalization (LSF) of complex substrates. Initial mechanistic studies point towards an inner‐sphere mechanism involving bis‐cyclometallated species shedding light on the general mechanistic understanding of ortho‐selective C–H borylations.
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