Targeting the crosstalk between glutamine metabolism and tumor immune microenvironment for lung cancer immunotherapy

Abstract Lung cancer remains one of the deadliest cancers globally, which may be attributed in part to a limited understanding of its development. Therefore, exploration of the fundamental processes of lung cancer and innovative therapies is imminent. Recently, lung cancer immunotherapy has become a crucial topic of interest, and it pertains to the metabolism in lung tumor microenvironment. In particular, glutamine metabolism plays a pivotal role in lung cancer immunotherapy. This review summarizes the crosstalk between glutamine metabolism and the lung tumor immune microenvironment, and explores potential strategies of glutamine metabolism as an enhancement of lung cancer immunotherapy. It also discusses the potential of traditional Chinese medicine in regulating glutamine metabolism in lung cancer immunotherapy. This review may offer valuable insights and promising directions for future studies on this subject.