Predictive Value of Serum sIL‐2R Levels and Th17/Treg Immune Balance for Disease Progression in Patients With Rheumatoid Arthritis‐Associated Interstitial Lung Disease

医学 类风湿性关节炎 间质性肺病 免疫学 内科学 免疫系统 胃肠病学
作者
Yaxiong Jin,Yixue Guo,Bin Ding,Ling Tang,Chunying Zhang,Yang Fu,Yong He,Qian Niu
出处
期刊:International Journal of Rheumatic Diseases [Wiley]
卷期号:28 (3)
标识
DOI:10.1111/1756-185x.70151
摘要

This article analyzed the relationship between serum sIL-2R levels and Th17/Treg immune balance in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and their prognostic value. RA patients (n = 311) were retrospectively selected for research and then allocated to the RA and RA-ILD groups. Baseline data and 3-year follow-up records of all patients were attained to assess disease progression. Serum sIL-2R levels were examined with ELISA, and Th17 and Treg cell clusters were tested with flow cytometry, followed by the calculation of the Th17/Treg ratio. The correlation of serum sIL-2R with Th17/Treg and related cytokines (IL-17, IL-6, IL-10, and TGF-β1) in RA-ILD patients were analyzed with Spearman's analysis. ROC curves were plotted for analyzing the performance of serum sIL-2R levels and the Th17/Treg ratio for predicting disease progression in RA-ILD patients. A multivariate Cox regression model was developed to screen independent risk factors for disease progression in RA-ILD patients. RA-ILD patients had elevated serum levels of sIL-2R, Th17 cells, IL-17, and IL-6 and an increased ratio of Th17/Treg, accompanied by a decreased Treg cell population and IL-10 and TGF-β1 levels. Serum sIL-2R levels were correlated positively with IL-17 levels and the Th17/Treg ratio in RA-ILD patients and negatively with IL-10 levels. DAS28 scores, serum sIL-2R levels, and an elevated Th17/Treg ratio were independent risk factors for disease progression in RA-ILD patients, and increased FEV1 and FEV1/FVC were protective factors. Serum sIL-2R levels in conjunction with Th17/Treg immune balance can assist in predicting 3-year disease progression in RA-ILD patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Lucas应助syf采纳,获得10
刚刚
lalala发布了新的文献求助10
刚刚
zxdnbb发布了新的文献求助10
刚刚
Ava应助璐洋采纳,获得10
1秒前
Smile应助zhanghaonan采纳,获得20
1秒前
kekeli发布了新的文献求助10
1秒前
量子星尘发布了新的文献求助10
1秒前
2秒前
传奇3应助yyy采纳,获得10
3秒前
3秒前
DE发布了新的文献求助30
3秒前
CipherSage应助111采纳,获得10
3秒前
汉堡包应助王小凡采纳,获得20
4秒前
hanjresearch发布了新的文献求助10
4秒前
4秒前
Ryann发布了新的文献求助10
4秒前
4秒前
川农辅导员完成签到,获得积分10
5秒前
darqin应助实习生ss采纳,获得10
5秒前
5秒前
Gemini发布了新的文献求助10
5秒前
5秒前
SHY完成签到 ,获得积分10
6秒前
6秒前
科研通AI5应助吃的采纳,获得10
6秒前
飘了完成签到,获得积分10
6秒前
渡繁完成签到 ,获得积分10
7秒前
7秒前
7秒前
CCC应助水门采纳,获得10
8秒前
所所应助DE采纳,获得10
8秒前
8秒前
呆萌棒棒糖完成签到,获得积分10
9秒前
9秒前
浮游应助妩媚的白玉采纳,获得10
9秒前
猪猪hero发布了新的文献求助10
9秒前
Adesanya发布了新的文献求助10
10秒前
科研通AI6应助yqlmncl采纳,获得10
10秒前
10秒前
智智发布了新的文献求助10
10秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Разработка технологических основ обеспечения качества сборки высокоточных узлов газотурбинных двигателей,2000 1000
Optimization and Learning via Stochastic Gradient Search 500
Nuclear Fuel Behaviour under RIA Conditions 500
Why America Can't Retrench (And How it Might) 400
Higher taxa of Basidiomycetes 300
Ricci Solitons in Dimensions 4 and Higher 240
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 物理化学 基因 催化作用 遗传学 冶金 电极 光电子学
热门帖子
关注 科研通微信公众号,转发送积分 4688750
求助须知:如何正确求助?哪些是违规求助? 4061435
关于积分的说明 12557156
捐赠科研通 3758855
什么是DOI,文献DOI怎么找? 2075942
邀请新用户注册赠送积分活动 1104622
科研通“疑难数据库(出版商)”最低求助积分说明 983700