钙
荧光
钙信号传导
生物医学中的光声成像
磁共振成像
细胞内
光学成像
生物学中的钙
生物物理学
化学
纳米技术
材料科学
生物化学
生物
医学
物理
光学
有机化学
放射科
作者
Grégory Thiabaud,Miriam Schwalm,Sajal Sen,Ali Barandov,Jacob C. Simon,P. K. Harvey,Virginia Spanoudaki,Péter Müller,Jonathan L. Sessler,Alan Jasanoff
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2023-10-09
卷期号:8 (10): 3855-3861
标识
DOI:10.1021/acssensors.3c01387
摘要
The ability to monitor intracellular calcium concentrations using fluorescent probes has led to important insights into biological signaling processes at the cellular level. An important challenge is to relate such measurements to broader patterns of signaling across fields of view that are inaccessible to optical techniques. To meet this need, we synthesized molecular probes that couple calcium-binding moieties to lanthanide texaphyrins, resulting in complexes endowed with a diverse complement of magnetic and photophysical properties. We show that the probes permit intracellular calcium levels to be assessed by fluorescence, photoacoustic, and magnetic resonance imaging modalities and that they are detectable by multimodal imaging in brain tissue. This work thus establishes a route for monitoring signaling processes over a range of spatial and temporal scales.
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