脚手架
光热治疗
骨肉瘤
间充质干细胞
再生(生物学)
癌细胞
骨髓
化学
生物医学工程
光热效应
癌症研究
材料科学
癌症
纳米技术
细胞生物学
病理
医学
生物
内科学
作者
Guannan Zhang,Ying Lu,Jianbo Song,Di Huang,Meiwen An,Weiyi Chen,Peide Han,Xiaohong Yao,Xiangyu Zhang
标识
DOI:10.1016/j.jcis.2023.08.176
摘要
After resection of bone tumour, the risk of cancer recurrence and numerous bone defects continues to threaten the health of patients. To overcome the challenge, we developed a novel multifunctional scaffold material consisting mainly of nano-hydroxyapatite particles (n-HA), MXene nanosheets and g-C3N4 to prevent tumour recurrence and promote bone formation. N-HA has the potential to restrict the growth of osteosarcoma cells, and the combination of MXene and g-C3N4 enables the scaffolds to produce photodynamic and photothermal effects simultaneously under near infrared (NIR) irradiation. Surprisingly, n-HA can further enhance the synergistic anti-tumour function of photodynamic and photothermal, and the scaffolds can eradicate osteosarcoma cells in only 10 min at a mild temperature of 45 ℃. Moreover, the scaffold exhibit exceptional cytocompatibility and possesses the capacity to induce osteogenic differentiation of bone marrow mesenchymal stem cells. Therefore, this multifunctional scaffold can not only inhibits the proliferation of bone tumour cells and rapidly eradicate bone tumour through NIR irradiation, but also enhances osteogenic activity. This promising measure can be used to treat tissue damage after bone tumour resection.
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