化学
炔丙基
催化作用
炔丙醇
共轭体系
酒
药物化学
四级碳
重排反应
有机化学
对映选择合成
聚合物
作者
Ram Singh Jat,M. Bhanuchandra
标识
DOI:10.1021/acs.joc.3c01387
摘要
Meyer–Schuster rearrangement of 3°-propargyl alcohol to the corresponding α,β-unsaturated carbonyl compounds under SOCl2 catalysis has been reported. Terminal and internal propargyl alcohols efficiently participated in the reaction. Furthermore, we have demonstrated the synthetic utility of conjugated carbonyl compounds to access densely arene-substituted pyrazolines bearing quaternary centers by reacting with arylhydrazine hydrochloride. Isotopic labeling studies were carried out to gain insights into the reaction mechanism.
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