特雷姆2
趋化因子
CXCL16型
CXCL14型
CXCL9型
细胞生物学
CXCL10型
脂多糖
CXCL2型
小胶质细胞
化学
CCL7型
CXCL11型
趋化因子受体
CCL25型
C-C趋化因子受体6型
受体
CCL21型
生物
趋化因子受体
免疫学
炎症
生物化学
作者
Kenjiro Bandow,Avi Smith,Jonathan Garlick
标识
DOI:10.1016/j.bbrc.2022.10.048
摘要
TREM2 (Triggering receptor expressed on myeloid cells 2) is the causative gene for Nasu-Hakola disease, which is characterized by multiple bone cysts and leukoencephalopathy. In addition, mutations in this gene have been found to be correlated with the onset of Alzheimer's disease. TREM2 is an immunoreceptor expressed on dendritic cells, microglia, osteoclasts, and macrophages. TREM2 on the cell membrane is shed by some proteases and released as soluble TREM2 (sTREM2). Meanwhile, several TREM2 ligands have been reported, and lipopolysaccharide (LPS) is one of the candidates. Using RNA interference to examine TREM2-mediated LPS response in macrophages, we identified five chemokines whose expression was induced via TREM2. Furthermore, we showed that LPS-induced expression of CXC-motif chemokine ligand (Cxcl10) and Cxcl11 among the five chemokines was mediated in part through sTREM2. These results suggest that sTREM2 has cytokine-like functions in macrophages.
科研通智能强力驱动
Strongly Powered by AbleSci AI