乙酸乙酯
抗菌剂
哈茨木霉
化学
曲霉
红树林
传统医学
烟曲霉
消炎药
次生代谢物
代谢物
生物
植物
生物化学
微生物学
药理学
医学
生物病虫害防治
基因
生态学
作者
Avinash Awashank,Abhay B. Fulke,G. Udhaba Dora,J. S. Karthi,Supriya Tilvi
标识
DOI:10.1080/14786419.2023.2301007
摘要
Mangrove ecosystem is diverse habitat for number of medicinally important microorganisms including fungi. Scientific research from last three decade emphasises it potential in important secondary metabolites production, which have wide biological activities. The current study elaborates isolation of fungi from pneumatophore of mangrove plant Avicennia marina and investigation of ethyl acetate extract for antimicrobial, anti-inflammatory and anticancer activity. Ethyl acetate extract of the fungus displayed maximum anti-inflammatory activity with 76.39% inhibition for by protein denaturation method and 22.52% inhibition for membrane stabilisation method with respect to standard ibuprofen. Further, the anticancer activity of Aspergillus stellatus LM-03 exhibited against MCF-7 of breast cancer cell with an IC50 value of 33.24 µg/ml. HPLC and UPLC-ESI-QTOF analysis displayed nine compound mainly alternariol monomethyl ether and methyl jasmonate, which are highly anticancer activity and moderate anti-inflammatory activity with other compounds as angelic anhydride, DL-3-(4-Hydroxyphenyl)lactic acid, 8,9-epoxyl-3-isobutyryloxy-10-(2-methylbutanoyl)thymol, 5-(6-methyl-7-oxooctyl) furan-2(5H)-one and phenyl-butyryl-glutamine with an unidentified compounds. The results of the current study indicate that it may be worthwhile to investigate Aspergillus stellatus LM-03 extract for promising bioactive metabolites with potential for medicinal use.
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