Self-assembled metal-polyphenol nanomedicines for tumor chemotherapy/chemokinetic synergistic therapy

Abstract Chemodynamic therapy (CDT) converts endogenous H 2 O 2 into highly toxic reactive oxygen species through the Fenton reaction or Fenton-like reaction. With the “one-pot” approach, the nanodrug EGCG-Cu-cisplatin NPs were created. The nanodrug has a particle size of approximately 150 nm and a homogeneous spherical shape. In vitro, results showed that the nanodrug degraded in a weakly acidic environment and released Cu 2+ and cisplatin. Cisplatin raises intracellular H 2 O 2 through a cascade reaction, Cu 2+ consumes GSH while generating Cu + . Cu + catalyzes H 2 O 2 to generate •OH, which breaks the intracellular redox balance, induces ferroptosis, reduces tumor resistance, and promotes chemotherapy. CDT uses the Fenton /Fenton-like reaction to transform endogenous H 2 O 2 into extremely hazardous reactive oxygen species.