泛发性脓疱性银屑病
银屑病
医学
皮肤病科
脓疱性银屑病
白细胞介素
免疫学
细胞因子
作者
Tuba Bukhari,Mariya Markovina,Abrahim Abduelmula,Brian D. Rankin,Ronald Vender,Jensen Yeung,Alim Devani,Vimal H. Prajapati
出处
期刊:PubMed
日期:2024-01-01
卷期号:29 (1): 1-4
摘要
Generalized pustular psoriasis (GPP) is a rare, immune-mediated inflammatory disease with characteristic cutaneous and systemic manifestations. Mutations in the interleukin-36 receptor antagonist (IL36RN) gene have been implicated in its pathogenesis. Spesolimab is a novel systemic biologic therapy that selectively inhibits interleukin-36. It was recently approved by Health Canada and the US FDA for the treatment of GPP flares in adults. Results from phase 1 and 2 studies have been promising. Herein, we review the efficacy and safety of spesolimab for the treatment of GPP flares, as demonstrated in clinical trials.
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