胶束
药物输送
两亲性
姜黄素
药品
控制释放
纳米医学
荧光团
化学
纳米技术
动力学
材料科学
共聚物
生物物理学
荧光
聚合物
组合化学
纳米颗粒
药理学
有机化学
生物化学
水溶液
医学
物理
量子力学
生物
作者
Sicheng Tang,Yuhan Gao,Wei Wang,Yijian Wang,Lingyun Pan,Zeyu Shou,Ruhui Yang,Chaofan Jin,Xingjie Zan,Chenglong Wang,Wujun Geng
标识
DOI:10.1021/acsmacrolett.3c00668
摘要
The development of drug delivery systems with real-time cargo release monitoring capabilities is imperative for optimizing nanomedicine performance. Herein, we report an innovative self-reporting drug delivery platform based on a ROS-responsive random copolymer (P1) capable of visualizing cargo release kinetics via the activation of an integrated fluorophore. P1 was synthesized by copolymerization of pinacol boronate, PEG, and naphthalimide monomers to impart ROS-sensitivity, hydrophilicity, and fluorescence signaling, respectively. Detailed characterization verified that P1 self-assembles into 11 nm micelles with 10 μg mL–1 CMC and can encapsulate hydrophobic curcumin with 79% efficiency. Fluorescence assays demonstrated H2O2-triggered disassembly and curcumin release with concurrent polymer fluorescence turn-on. Both in vitro and in vivo studies validated the real-time visualization of drug release and ROS scavenging, as well as the therapeutic effect on osteoarthritis (OA). Overall, this nanotheranostic polymeric micelle system enables quantitative monitoring of drug release kinetics for enhanced treatment optimization across oxidative stress-related diseases.
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