PhIO Mediated One‐Pot Synthesis of Pyrroloquinolinediones from ortho‐Carbonyl Anilines and Maleimides

Abstract An effective, green, mild, and metal‐free hypervalent iodine‐mediated approach for the synthesis of pyrroloquinolinediones from ortho ‐carbonyl anilines and maleimides in a one‐pot manner at room temperature has been developed. This proposed protocol can synthesize biologically active pyrroloquinolinediones in a one‐pot manner utilizing readily available starting materials. This protocol generates H 2 O as the only by‐product during the reaction and shows a high atom economy. Operational simplicity, moderate reaction conditions, high atom economy, and high yield are some key features of this protocol.