癌症干细胞
临床试验
生物
癌症
癌症治疗
干细胞
癌症研究
生物信息学
肿瘤科
医学
遗传学
作者
Alex Philchenkov,Anna Dubrovska,Anna Dubrovska,Anna Dubrovska,Anna Dubrovska,Anna Dubrovska,Anna Dubrovska,Anna Dubrovska
出处
期刊:Stem Cells
[Wiley]
日期:2023-12-14
卷期号:42 (3): 173-199
标识
DOI:10.1093/stmcls/sxad092
摘要
The key role of cancer stem cells (CSCs) in tumor development and therapy resistance makes them essential biomarkers and therapeutic targets. Numerous agents targeting CSCs, either as monotherapy or as part of combination therapy, are currently being tested in clinical trials to treat solid tumors and hematologic malignancies. Data from ongoing and future clinical trials testing novel approaches to target tumor stemness-related biomarkers and pathways may pave the way for further clinical development of CSC-targeted treatments and CSC-guided selection of therapeutic regimens. In this concise review, we discuss recent progress in developing CSC-directed treatment approaches, focusing on clinical trials testing CSC-directed therapies. We also consider the further development of CSC-assay-guided patient stratification and treatment personalization.
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