再生(生物学)
糖胺聚糖
细胞生物学
血小板源性生长因子受体
化学
壳聚糖
干细胞
生长因子
血小板衍生生长因子
癌症研究
生物医学工程
医学
受体
生物化学
生物
作者
Luli Ji,Yuanman Yu,Fuwei Zhu,David C.S. Huang,Xiaogang Wang,Jing Wang,Changsheng Liu
标识
DOI:10.1016/j.bioactmat.2023.12.016
摘要
Musculoskeletal injuries and bone defects represent a significant clinical challenge, necessitating innovative approaches for effective bone tissue regeneration. In this study, we investigated the potential of harnessing periosteal stem cells (PSCs) and glycosaminoglycan (GAG)-mimicking materials for in situ bone regeneration. Our findings demonstrated that the introduction of 2-N, 6-O sulfated chitosan (26SCS), a GAG-like polysaccharide, enriched PSCs and promoted robust osteogenesis at the defect area. Mechanistically, 26SCS amplifies the biological effect of endogenous platelet-derived growth factor-BB (PDGF-BB) through enhancing the interaction between PDGF-BB and its receptor PDGFRβ abundantly expressed on PSCs, resulting in strengthened PSC proliferation and osteogenic differentiation. As a result, 26SCS effectively improved bone defect repair, even in an osteoporotic mouse model with lowered PDGF-BB level and diminished regenerative potential. Our findings suggested the significant potential of GAG-like biomaterials in regulating PSC behavior, which holds great promise for addressing osteoporotic bone defect repair in future applications.
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