HDAC1型
医学
腺癌
肺
免疫
癌症研究
大肠腺癌
药理学
免疫学
内科学
化学
免疫系统
组蛋白
组蛋白脱乙酰基酶
癌症
基因
生物化学
作者
Tingting Xu,Yuan Fang,Yunru Gu,XU Duo,Tong Hu,Yu Tao,Yang-Yue Xu,Haoyang Shen,Pei Ma,Yongqian Shu
标识
DOI:10.1136/jitc-2024-010077
摘要
Our results revealed a novel mechanism by which the HDACi SAHA potentiates CD8+T-cell-mediated antitumor activity through the HDAC1/JAK1/FGL1 axis, providing a rationale for the combined use of HDACis and immunotherapy.
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