Efficient bionic nanozyme based on AuPt NPs@ZIF-90 used for cyclic catalysis multimodal tumor therapy

Multimodal therapy based on nanozyme is expected to become a novel option for tumor treatment. However, the catalytic efficiency of nanozymes and the hypoxia microenvironment of tumors limit the therapeutic effect of nanozymes. Herein, we screened a small molecule of midazole-2-carboxaldehyde (ICA) to prepare ZIF-90 and embedded gold and platinum nanoparticles to obtain ZAAP. ZAAP possessed a multi-enzymatic cascade of catalytic processes including greatly enhanced peroxidase activity