Efficient bionic nanozyme based on AuPt NPs@ZIF-90 used for cyclic catalysis multimodal tumor therapy

to generate ROS and peroxidase-induced oxygen generation for continuous oxidation of glucose. All the above processes built a catalysis cycle that greatly promotes the generation of ROS and oxygen as well as the consumption of glucose, leading to the chemical dynamic therapy function and alleviating tumor hypoxia. In addition to the photothermal effect of ZAAP, a synergistic treatment of chemical dynamic/photothermal/starvation therapy was achieved, and the tumor inhibition rate reached 96.4% within 2 weeks, indicating that ZAAP shows great potential in nanozyme-based synergistic multimodal tumor treatment.