Attention Deficit Hyperactivity Disorder (ADHD) is a disorder of early development resulting in impaired attention and overactivity. Using fully-automated voxel-based MRI analysis we found that, compared to age and IQ matched healthy controls, stringently diagnosed children with ADHD had on average a 4% reduction in white matter volume which was significant (p<0.05). There was no significant volumetric difference in global grey matter but we observed significant localized grey matter volume reductions in frontal and striatal regions. These results will be discussed in light of recent neuroimaging findings in ADHD.