蛋氨酸
生物
氧化应激
秀丽隐杆线虫
能量稳态
长寿
肥胖
生物信息学
医学
遗传学
生物化学
氨基酸
内分泌学
基因
作者
Yuyu Zhang,Julia Jelleschitz,Tilman Grune,Weixuan Chen,Yihang Zhao,Mengzhen Jia,Yajie Wang,Annika Höhn,Zhigang Liu
出处
期刊:Redox biology
[Elsevier]
日期:2022-09-01
卷期号:57: 102464-102464
被引量:1
标识
DOI:10.1016/j.redox.2022.102464
摘要
Methionine is an essential amino acid, involved in the promotion of growth, immunity, and regulation of energy metabolism. Over the decades, research has long focused on the beneficial effects of methionine supplementation, while data on positive effects of methionine restriction (MR) were first published in 1993. MR is a low-methionine dietary intervention that has been reported to ameliorate aging and aging-related health concomitants and diseases, such as obesity, type 2 diabetes, and cognitive disorders. In addition, MR seems to be an approach to prolong lifespan which has been validated extensively in various animal models, such as Caenorhabditis elegans, Drosophila, yeast, and murine models. MR appears to be associated with a reduction in oxidative stress via so far mainly undiscovered mechanisms, and these changes in redox status appear to be one of the underlying mechanisms for lifespan extension and beneficial health effects. In the present review, the association of methionine metabolism pathways with redox homeostasis is described. In addition, the effects of MR on lifespan, age-related implications, comorbidities, and diseases are discussed.
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