The prevalence of type 2 inflammatory signatures in patients with chronic rhinosinusitis with nasal polyps from two phase 3 clinical trials, SINUS-24 and SINUS-52

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease of the nasal cavity and paranasal sinuses characterized by type 2 inflammation. Recent publications described algorithms for identification of type 2 inflammation in CRSwNP without tissue analysis. We used these algorithms to assess the prevalence of type 2 inflammation in patients with severe CRSwNP from two phase 3 studies (SINUS-24/SINUS-52 [NCT02912468/NCT02898454]).