生物
免疫系统
细胞毒性T细胞
干扰素γ
主要组织相容性复合体
免疫学
干扰素
抗原
同型
受体
抗体
病毒学
单克隆抗体
体外
生物化学
作者
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Ján Vilček,Rolf M. Zinkernagel,Michel Aguet
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1993-03-19
卷期号:259 (5102): 1742-1745
被引量:1528
标识
DOI:10.1126/science.8456301
摘要
Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance, they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
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